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At 104 weeks (2 years), patients in this subgroup reached 30.3% average weight loss confirming that retatrutide doesn't plateau at the primary endpoint and continues to improve with extended treatment
Standard dosing protocol (monotherapy) Week-by-week titration: Week 1-4: 0.6mg weekly Week 5-8: 1.2mg weekly Week 9-12: 1.8mg weekly Week 13+: 2.4mg weekly (maintenance) Why slow titration: Reduces nausea and GI side effects Allows body to adapt Better long-term adherence Standard in all trials Injection details: Subcutaneous injection Abdomen, thigh, or upper arm Weekly dosing (same day each week) Rotate injection sites Duration of use: Minimum 68 weeks for maximum results Often 12-18 months Maintenance indefinite (to prevent regain) No defined end point Use our peptide calculator , peptide dosing guide , peptide dosage chart , and how to calculate peptide dosages at SeekPeptides
Discontinuation of semaglutide or tirzepatide typically produces measurable regain within 6 to 12 months (STEP 1 extension data
I listened to a bunch of things, one of which was a Tegus call with a professor of cardiology that cited about one out of six patients have side effects that are so severe that they discontinue the drug
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